Clinical and observational studies with plasma care®
Take a closer look at the studies conducted with our plasma care. If you have any further questions about a specific indication or the study situation in another area, we will be happy to help you personally.
Preclinical
Cold Atmospheric Plasma Promotes the Immunoreactivity of Granulocytes In Vitro
Kupke LS, Arndt S, Lenzer S, Metz S, Unger P, Zimmermann JL, Bosserhoff AK, Gruber M, Karrer S. Cold Atmospheric Plasma Promotes the Immunoreactivity of Granulocytes In Vitro. Biomolecules. 2021 Jun 17;11(6):902. doi: 10.3390/biom11060902. PMID: 34204360; PMCID: PMC8235417.
“The cell biological results of the study on the mouse model show that the change in immunoreactivity could be an important supporting mechanism for the CAP-induced improvement in wound healing. ”
Summary:
Cold atmospheric plasma (CAP) reduces bacteria and interacts with tissues and cells, thus improving wound healing. The CAP-related induction of neutrophils was recently described in stained sections of wound tissue in mice. Consequently, this study aimed to examine the functionality of human polymorphonuclear cells (PMN)/granulocytes through either a plasma-treated solution (PTS) or the direct CAP treatment with different plasma modes and treatment durations. In conclusion, the modification of PMN immunoreactivity may be a main supporting mechanism for CAP-induced improvement in wound healing.
Preclinical
Non-invasive Physical Plasma Modulates Macrophage Polarization: A Potential Strategy for Tumor Microenvironment Remodeling
Niu Y, Förster S, Badendieck S, Nokhbehsaim M, Abazid A, Stope MB. Non-invasive Physical Plasma Modulates Macrophage Polarization: A Potential Strategy for Tumor Microenvironment Remodeling. Anticancer Res. 2024 Jun;44(6):2437-2444. doi: 10.21873/anticanres.17050. PMID: 38821624.
“Cell morphology, viability, and proliferation were not affected by up to 6 minutes of NIPP treatment.”
Dr. M. Stope, Department of Gynecology and Gynecological Oncology, University Hospital Bonn
Summary:
Non-invasive physical plasma (NIPP) has shown promise in the treatment of cancer. However, conflicting results have been reported regarding the effect of NIPP on macrophage polarization. As tumor-associated macrophages (TAMs) are essential in the regulation of cancer development, this study aimed to determine the role of NIPP treatment in macrophage polarization and tumor-microenvironment (TME) remodeling. No significant changes were observed in temperature and pH value after NIPP treatment, while the formation of hydrogen peroxide was promoted in a time-dependent manner. Cell morphology, viability, and proliferation were not affected by up to 6 minutes of NIPP treatment.
Dermatology/Aesthetic
Other Indications
Non-invasive physical plasma for preventing radiation dermatitis in breast cancer: Results from an intrapatient-randomised double-blind placebo-controlled trial
Dejonckheere CS, et al. Non-invasive physical plasma for preventing radiation dermatitis in breast cancer: Results from an intrapatient-randomised double-blind placebo-controlled trial. Clin Transl Radiat Oncol. 2023 Nov 4;44:100699. doi: 10.1016/j.ctro.2023.100699. PMID: 38021092; PMCID: PMC10654149.
“The data suggest the potential benefit of NIPP in RD prevention. A randomised trial with a physical control group is warranted to confirm these promising results (DRKS00026225).”
Dr. Dejonckheere, Department of Radiation Oncology, University Hospital Bonn
Summary:
To investigate the effect of topical non-invasive physical plasma (NIPP), a volatile mix generated out of ambient air, on prevention of acute radiation dermatitis (RD) during and after whole-breast irradiation (WBI). Sixty-four patients were included. There were no significant differences between breast halves. Tolerability of NIPP was excellent and side effects were not observed. Even though there were no differences between intrapatient-randomised breast halves, the overall incidence and severity of acute radiation-induced skin toxicity were considerably lower when compared to a prospectively collected SoC cohort. Our data suggest the potential benefit of NIPP in RD prevention. A randomised trial with a physical control group is warranted to confirm these promising results (DRKS00026225).
Chronic Wounds
Cold plasma treatment for hard-to heal wounds
Gebhardt, Ascher. Cold plasma treatment for hard-to heal wounds. mecial-special (2022)
“The present cases show good tolerability of cold plasma therapy as well as clear indications
of the wound healing-promoting effect.”
Gebhardt/Ascher
Summary:
Cold atmospheric plasma (CAP) is increasingly being used to stimulate the healing of wounds that are difficult to heal. In the present case study, 12 patients with chronic wounds, some of which had been present for over a year, were treated with KAP. A significant reduction in wound size and a reduction in the pH value within the wound was observed.